Yoshitoshi's works are known for their dramatic and often macabre themes. He was particularly skilled in depicting historical and supernatural subjects, including warriors, ghosts, monsters, and scenes from Japanese folklore. His prints often featured intense and dynamic compositions, with a strong emphasis on expressive figures and intricate details.

During the Meiji period, Japan underwent significant social, political, and cultural changes as it transitioned from a feudal society to a modern nation. Yoshitoshi's prints reflected this period of transition, addressing themes such as the decline of traditional values, the impact of Westernization, and the conflicts of the time.

One of Yoshitoshi's most famous series is "One Hundred Views of the Moon," which consists of 100 prints depicting various scenes related to the moon. This series showcases his technical mastery and imaginative storytelling abilities.

Yoshitoshi's later works also explored psychological and emotional themes, often delving into the darker aspects of human nature. His prints were highly detailed and featured intricate linework, rich colors, and innovative use of perspective.

Despite facing personal and financial difficulties throughout his life, Yoshitoshi's artistic talent and dedication to his craft earned him recognition and admiration. His works continue to be highly regarded for their technical skill, creativity, and their portrayal of the changing landscape of Japan during the Meiji period.